Anticancer activity of Hibiscus rosa-sinensis’s Leaf


Hibiscus rosa-sinesis Linn. (Malvaceae) is a perennial ornamental shrub widely cultivated in the tropics. Hibiscus rosa L is native to china and is also seen in India and Philippines and it is a national flower of Malaysia. This hibiscus having several forms and varying colors sinensis of flowers…. MORE DETAILS AND IMAGES

Some of authors reported that the leaves and flowers of Hibiscus rosa-sinesis have healing properties (1, 2 & 3). Hibiscus rosa-sinensis leaves and flowers are observed to be promoters of hair growth (4). The researchers conformed that the hypoglycemic activity of Hibiscus rosa-sinesis is not mediated through insulin release and this increase the potential use of this hibiscus species for human health purposes.

Furthermore, there is very significant proof for the anticancer action of Hibiscus rosa-sinesis extract against the tumor promotion stage of cancer development, in mouse skin with ultraviolet radiation (5). In ancient Indian medicinal literature reported that the flowers of Hibiscus rosa-sinensis have valuable properties in heart diseases, mainly in myocardial ischemic disease, due to its enhancement of the myocardial endogenous antioxidants by an adaptative response and without producing any cytotoxic effects (6).

The aqueous leaf extract of Hibiscus rosa-sinensis was investigated against four human cancer cell lines such as HepG2, HT-29 And MCF-7 using MTT 3-(4,5-dimethylthiazol–2-yl)- 2,5-diphenyltetrazolium bromide and found to be active anticancerous agents. The results obtained from the cytotoxic activity of this plant exposed that further studies may lead to the progress of potent anticancer agents from leaf extract of Hibiscus rosa-sinensis. This finding may pave the way for the bioactivity guided fractionation and isolation of significant moieties for the anticancer chemotherapy and in part help to minimize the serious lacuna in scientific validation of these herbs (7).


  1. Nadkarni A.K., 1954 — Indian Materia Medica. Bombay, 631 pp.
  2. Ali m., Ansari, S.H., 1997 — Hair care and herbal drugs. Indian Journal of Natural Products, 13: 3-5.
  3. Kurup p.N.V., Ramdas V.N.K. and Joshi p., 1979 —Handbook of Medicinal Plants. New Delhi, 86 pp.
  4. Adhirajan n., Ravi K.T., Shanmugasundaram N. and Babu M., 2003 — In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. Journal of Ethnopharmacology, 88: 235-239.
  5. Sharma S., Khan N. and Sultana S. 2004b. Effect of Onosma echioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidativedamage in murine skin. Europ. Cancer Prevention. ;13: 40–53.
  6. Gauthaman K.K., Saleem M.T., Thanislas P.T., Prabhu V.V., Krishnamoorthy K.K., Devaraj N.S. and Somasundaram J.S. 2006. Cardioprotective effect of the Hibiscus rosasinensis flowers in an oxidative stress model of myocardial ischemic reperfusion injury in rat. BMC Complementary and Alternative Medicine.; 6: 32
  7. Divya MJ, Sowmia C, Dhanya KP, Joona K. Screening of antioxidant, anticancer activity and phytochemicals in methanolic extract of Hibiscus rosa-sinensis leaf extract. Res J Pharmaceut Biol Chem Sci 2013;4:1308-1316.