ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITIES OF HIBISCUS TILIACEUS (L.) FLOWERS

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ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITIES OF HIBISCUS TILIACEUS (L) FLOWERS

Hibiscus tiliaceus L. (bola) is a mangrove plant growing in tropical Asia and abundant in forests. In folk medicine, the leaves of this hibiscus species use to treat fevers, soothe coughs, wounds, ulcer and various skin diseases (1). The fruit juice of Hibiscus tiliaceus is rubbed on skin to cure weakness (2-4). The flower extract also exhibited significant reducing power and free radical scavenging effect on hydroxyl, superoxide, hydrogen peroxide radicals(1). Hibiscus tiliaceus indicated antinociceptive and anti-inflammatory effects (5). Traditionally, it has been used for diabetes (6). Furthermore, Hibiscus rosa sinensis and Hibiscus sabdariffa from the same genus has antidiabetic effect (7-8). In Indian Hibiscus tiliaceus had been used as laxative, febrifuge, resolvent and emollient. An infusion of leave of this hibiscus is engaged to wash ulcer and wounds.

Antidiabetic and hypolipidemic activities were carried out by Kumar to evaluate of Hibiscus tiliaceus methanolic flowers extract in streptozotocin induced diabetic wistar rat by administering graded oral doses (250 and 500 mg/kg body weight) for 21 days. The flower extract exhibited significant antidiabetic activity with significant improvement in body weight of tested animals. Daily oral treatment with the flower extract for 21 days also resulted in significantly reduction serum cholesterol and triglycerides. HDL-cholesterol level was found to be improved as compared to diabetic control group in this study (9).

References

  1. Narender, Kumar S, Kumar D, Kumar V. Antinociceptive and AntiInflammatory Activity of Hibiscus tiliaceus Leaves, IJPPR 2009, 1(1): 15-17.
  2. Nadkarni KM. Indian Materia Medica. 3rd edition, Vol. I, Popular Parkashan, Mumbai, India, 2005: 633.
  3. Kirtikar KR, Basu BD. Indian Medicinal Plants. Vol. II, Oriental Enterprises, Dehradun, India, 2003:459. 10. Prajapati ND, Purohit SS, Sharma AK, Kumar T. A Hand Book of Medicinal Plants: A Complete Source Book. Agrobios India, 2003:271
  4. Kumar S, Kumar D, Prakash O. Evaluation of antioxidant potential, phenolic and flavonoid contents of Hibiscus tiliaceus flowers, EJEAFChe 2008; 7 (4), 2863-2871.
  5. Kumar S, Kumar D, Prakash O. Evaluation of antioxidant potential, phenolic and flavonoid contents of Hibiscus tiliaceus flowers, EJEAFChe 2008; 7 (4), 2863-2871.
  6. Sood SK, Bhardwaj R, Lakhanpal TN. Ethnic Indian Plants in cure of diabetes. Scientific publishers( India), Jodhpur, 2005: 77-78.
  7. Sachdewa A, Khemani LD. Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats. J Ethnopharmacol 2003; 89(1):61-66.
  8. Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F. Effects of sour tea (Hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type II diabetes. J Altern Complement Med 2009; 15(8):899-903.
  9. S. Kumar, V. Kumar and Om Prakash. Antidiabetic and hypolipidemic activities of hibiscus tiliaceus (l.) Flowers extract in streptozotocin induced diabetic rats. Pharmacologyonline (2010), 2: 1037-1044

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