HIBISCUS ROSE-SINENSIS’S FLOWER AND CANCER PREVENTION

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HIBISCUS ROSE-SINENSIS'S FLOWER AND CANCER PREVENTION

Hibiscus rosa-sinesis Linn. (Malvaceae) is a perennial ornamental shrub widely cultivated in the tropics. Hibiscus rosa sinensis L is native to china and is also seen in India and Philippines and it is a national flower of Malaysia. This hibiscus having several forms and varying colors of flowers. Various extract of Hibiscus rosa-sinensis exposed the presence of glycosides, alkaloids, fatty materials, resin, reducing sugars, sterols and the lack of tannins and Saponins. Isolation of taraxeryl acetate, β-sitosterol, and four uncharacterized compounds which included an alkaloid and three sterols has been reported in the leaves. The leaves of Hibiscus rosa-sinensis were also studied for their fatty acids fatty alcohol, and hydrocarbon content. Two cyclic acids viz., malvalic and sterculic are also identified. Flowers contain flavonoids, vitamins, ascorbic acid, niacin, thiamine, riboflavin and cyaniding diglucoside. Cyanidin-3-sophoroside-5-glycosides, 3, 7- diglucoside, cyanidin-3, Quercetin-3-diglucoside, 5-diglucoside have been isolated from deep yellow flowers….MORE DETAILS ANDIMAGES

The leaves and flowers of Hibiscus rosa-sinesis have healing properties (1, 2 & 3). Flowers have been found to be effective as natural medicine in the treatment of arterial hypertension (4) and to have significant anti-fertility effect (5 & 6). Hibiscus rosa-sinesis leaves and flowers are detected to be promoters of hair growth (7). The researchers conformed that the hypoglycemic activity of Hibiscus rosa-sinesis is not mediated through insulin release and this increase the potential use of this hibiscus species for human health purposes.

Furthermore, there is very significant proof for the anticancer action of Hibiscus rosa-sinesis extract against the tumor promotion stage of cancer development, in mouse skin with ultraviolet radiation (8). In ancient Indian medicinal literature reported that the flowers of Hibiscus rosa-sinesis have valuable properties in heart diseases, mainly in myocardial ischemic disease, due to its enhancement of the myocardial endogenous antioxidants by an adaptative response and without producing any cytotoxic effects (9). Reports showed that hibiscus extracts can inhibit the growth of cancer cell types such as leukemia (10), mammary carcinoma (11) and melanoma (12). However, while Hibiscus rosa-sinesis flowers are commonly used to make medicinal tea (13 & 14 ). Goldberg et al 2017 investigated that anticancer activity of Hibiscus rosa-sinesis flower extract against melanoma cell growth. Results of this study from indicated that H. rosa-sinensis tea extracts contain compounds that inhibit melanoma cell growth at concentrations that do not affect nontransformed cells.

References

  1. Nadkarni A.K., 1954 — Indian Materia Medica. Bombay, 631 pp.
  2. Ali m., Ansari, S.H., 1997 — Hair care and herbal drugs. Indian Journal of Natural Products, 13: 3-5.
  3. Kurup p.N.V., Ramdas V.N.K. and Joshi p., 1979 —Handbook of Medicinal Plants. New Delhi, 86 pp.
  4. Dwivedi R.N., Pandey S.P. and Tripathi, V.J., 1977 — Role of japapushpa (Hibiscus rosa-sinensis) in the treatment of arterial hypertension. A trial study. Journal of Research in Indian Medicine, Yoga & Homeopathy, 12: 13-36.
  5. Singh M.P., Singh R.H. and Udupa, K.N., 1982 — Antifertility activity of a benzene extract of Hibiscus rosa-sinensis flowers on female albino rats. Planta Medica, 44: 171-174.
  6. Sethi N., Nath D. and Singh R.K., 1986 — Teratological study of an indigenous antifertility medicine, Hibiscus rosa-sinensis in rats. Arogya Journal of Health Science, 12: 86-88.
  7. Adhirajan n., Ravi K.T., Shanmugasundaram N. and Babu M., 2003 — In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. Journal of Ethnopharmacology, 88: 235-239.
  8. Sharma S., Khan N. and Sultana S. 2004b. Effect of Onosma echioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidativedamage in murine skin. Europ. Cancer Prevention. ;13: 40–53.
  9. Gauthaman K.K., Saleem M.T., Thanislas P.T., Prabhu V.V., Krishnamoorthy K.K., Devaraj N.S. and Somasundaram J.S. 2006. Cardioprotective effect of the Hibiscus rosasinensis flowers in an oxidative stress model of myocardial ischemic reperfusion injury in rat. BMC Complementary and Alternative Medicine.; 6: 32
  10. Tsai TC, Huang HP, Chang YC, Wang CJ. 2014. An anthocyanin-rich extract from Hibiscus sabdariffa linnaeus inhibits N-nitrosomethylurea-induced leukemia in rats. J Agric Food Chem.; 62 : 1572-1580.
  11. Hsu RJ, Hsu YC, Chen SP, et al. 2015The triterpenoids of Hibiscus syriacus induce apoptosis and inhibit cell migration in breast cancer cells. BMC Complement Altern Med.;15 : 65.
  12. Chiu CT, Hsuan SW, Lin HH, Hsu CC, Chou FP, Chen JH. Hibiscus sabdariffa leaf polyphenolic extract induces human melanoma cell death, apoptosis, and autophagy. J Food Sci. 2015; 80 : 649- 658.
  13. Mishra N, Tandon VL, Gupta R. Immunomodulation by Hibiscus rosa-sinensis: effect on the humoral and cellular immune response of Mus musculus. Pak J Biol Sci. 2012; 15 : 277e283.
  14. Jadhav VM, Thorat RM, Kadam VJ, Sathe NS. Traditional medicinal uses of Hibiscus rosa-sinensis. J Pharm Res. 2009; 2: 1220e1222.
  15. Karina H. Goldberg, Ariel C. Yin, Archana Mupparapu , Edward P. Retzbach , Gary S. Goldberg , Catherine F. Yang . Components in aqueous Hibiscus rosa-sinensis flower extract inhibit in vitro melanoma cell growth. Journal of Traditional and Complementary Medicine 7 (2017) 45-49.

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